Efficient syntheses of novel C2'-alkylated (+/-)-K252a analogues.
Tamaki K, Shotwell JB, White RD, Drutu I, Petsch DT, Nheu TV, He H, Hirokawa Y,
Maruta H, Wood JL.
Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New
Haven, Connecticut 06520-8107, USA.
Recent efforts in our laboratories have resulted in a synthetic approach toward
C2'-alkylated K252a analogues via extension of a K252a cyclofuranosylation
strategy. The bis-indole-N-glycosidic coupling of
6-N-(3,4-dimethoxybenzyl)-staurosporinone (21) with a number of highly
functionalized carbohydrates has given access to previously unattainable,
biologically relevant analogues.
Publication Types:
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
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